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GENERIC NAME: duloxetine Model: generic Cymbalta

DRUG CLASS AND MECHANISM: Duloxetine is known as a selective serotonin and norepinephrine reuptake inhibitor (SNRI) ideal for treating depression, anxiety disorder and pain involving diabetic peripheral neuropathy or fibromyalgia. Other drugs through this class include milnacipran (Savella), venlafaxine (Effexor), and desvenlafaxine (Pristiq). Duloxetine affects neurotransmitters, the chemicals that nerves in the brain make and release so that they can contact eath other. Neurotransmitters either travel along the space between nerves and attach to receptors at first of nearby nerves or they stay with receptors at first glance within the nerves that produced them, for being taken up by way of the nerve and released again (a procedure referred to as re-uptake).

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Most pros think that an imbalance among neurotransmitters is a cause of depression and various other psychiatric disorders. Serotonin and norepinephrine are two neurotransmitters released by nerves in the brain. Duloxetine functions preventing the reuptake of serotonin and epinephrine by nerves after they happen to be released. Since uptake is an essential mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, time frame uptake as a result of duloxetine boosts the effect of serotonin and norepinephrine using the brain. The mechanism the cause of its effectiveness treating pain is just not known and is thought to involve its effects on serotonin and norepinephrine inside the brain. Duloxetine was authorized by the FDA in August 2004.

PREPARATIONS: Delayed-release capsules: 20, 30, and 60 mg

STORAGE: Capsules ought to be stored at room temperature, between 15 to 30 C (59 to 86 F).

PRESCRIBED FOR: Duloxetine can be used for the treatment of depression, generalized panic attack, and pain related to diabetic peripheral neuropathy or fibromyalgia.

DOSING: The recommended dose to treat depression is 20 or 30 mg two tmes a day or 60 mg once daily. Patients could be started with 30 mg once daily personally week prior to a dose is advanced to 60 mg daily. The recommended dose for panic, pain involving diabetic neuropathy or fibromyalgia is 60 mg daily. There's really no evidence that doses more than 60 mg/day provide additional benefits.

DRUG INTERACTIONS: Duloxetine must not be utilized in in conjunction with a monoamine oxidase inhibitor (MAOI) just like phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), and selegiline (Eldepryl), or within Fourteen days of discontinuing the MAOI. A minimum of 5 days must be allowed after stopping duloxetine before you begin an MAOI. Combinations of SNRIs and MAOIs may cause serious, sometimes fatal, reactions including really large body's temperature, muscle rigidity, rapid fluctuations of heart beat and bp, extreme agitation progressing to delirium, and coma. Similar reactions can happen if duloxetine is coupled with antipsychotics, tricyclic antidepressants or some other drugs which affect serotonin inside brain (including, tryptophan, and sumatriptan (Imitrex).