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GENERIC NAME: duloxetine Manufacturer: generic cymbalta

DRUG CLASS AND MECHANISM: Duloxetine is actually a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used in treating depression, panic attacks and pain regarding diabetic peripheral neuropathy or fibromyalgia. Other drugs about this class include milnacipran (Savella), venlafaxine (Effexor), and desvenlafaxine (Pristiq). Duloxetine affects neurotransmitters, the harmful chemicals that nerves inside brain make and release so that you can contact the other person. Neurotransmitters either travel through the entire space between nerves and fasten to receptors on the outside of nearby nerves or they accompany receptors on top of the nerves that produced them, to obtain taken up by nerve and released again (a procedure referred to as re-uptake).

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Most pros think that an imbalance among neurotransmitters may be the cause of depression along with other psychiatric disorders. Serotonin and norepinephrine are a couple of neurotransmitters released by nerves using the brain. Duloxetine operates by preventing the reuptake of serotonin and epinephrine by nerves after they happen to be released. Since uptake can be a mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, the fewer uptake because of duloxetine increases the effect of serotonin and norepinephrine from the brain. The mechanism the reason behind its effectiveness treating pain is just not known but additionally is thought to involve its effects on serotonin and norepinephrine within the brain. Duloxetine was licensed through the FDA in August 2004.

PREPARATIONS: Delayed-release capsules: 20, 30, and 60 mg

STORAGE: Capsules must be stored at room temperature, between 15 to 30 C (59 to 86 F).

PRESCRIBED FOR: Duloxetine is employed for the treatment of depression, generalized anxiety, and pain involving diabetic peripheral neuropathy or fibromyalgia.

DOSING: The recommended dose for the treatment of depression is 20 or 30 mg twice a day or 60 mg once daily. Patients could possibly be began with 30 mg once daily for starterst week until the dose is advanced to 60 mg daily. The recommended dose for panic attacks, pain regarding diabetic neuropathy or fibromyalgia is 60 mg daily. There is not any evidence that doses over 60 mg/day provide additional benefits.

DRUG INTERACTIONS: Duloxetine mustn't be found in conjunction with a monoamine oxidase inhibitor (MAOI) including phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), and selegiline (Eldepryl), or within Two to three weeks of discontinuing the MAOI. At the very least Five days should be allowed after stopping duloxetine before beginning an MAOI. Mixtures of SNRIs and MAOIs may lead to serious, sometimes fatal, reactions including extremely high body's temperature, muscle rigidity, rapid fluctuations of and hypotension, extreme agitation progressing to delirium, and coma. Similar reactions will occur if duloxetine is together with antipsychotics, tricyclic antidepressants along with other drugs affecting serotonin during the brain (for instance, tryptophan, and sumatriptan (Imitrex).