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GENERIC NAME: duloxetine Model: generic Cymbalta (Duloxetine)

DRUG CLASS AND MECHANISM: Duloxetine is generally a selective serotonin and norepinephrine reuptake inhibitor (SNRI) utilized by treating depression, panic attacks and pain involving diabetic peripheral neuropathy or fibromyalgia. Other drugs during this class include milnacipran (Savella), venlafaxine (Effexor), and desvenlafaxine (Pristiq). Duloxetine affects neurotransmitters, the harmful chemicals that nerves inside the brain make and release to be able to communicate with the other person. Neurotransmitters either travel through the entire space between nerves and connect to receptors seems to of nearby nerves or they connect to receptors at first glance within the nerves that produced them, to remain taken up by way of the nerve and released again (an activity referred to as re-uptake).

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Most pros think that an imbalance among neurotransmitters can be a reason for depression and other psychiatric disorders. Serotonin and norepinephrine are two neurotransmitters released by nerves inside the brain. Duloxetine functions preventing the reuptake of serotonin and epinephrine by nerves because they have been released. Since uptake is a vital mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, period of time uptake a result of duloxetine raises the effect of serotonin and norepinephrine within the brain. The mechanism in control of its effectiveness treating pain seriously isn't known as well as is thought to involve its effects on serotonin and norepinephrine in the brain. Duloxetine was authorized by the FDA in August 2004.

PREPARATIONS: Delayed-release capsules: 20, 30, and 60 mg

STORAGE: Capsules must be stored at 70 degrees, between 15 to 30 C (59 to 86 F).

PRESCRIBED FOR: Duloxetine is required to treat depression, generalized panic attacks, and pain involving diabetic peripheral neuropathy or fibromyalgia.

DOSING: The recommended dose for the treatment of depression is 20 or 30 mg 2 times a day or 60 mg once daily. Patients could be began with 30 mg once daily for 1 week before the dose is advanced to 60 mg daily. The recommended dose for panic disorder, pain linked to diabetic neuropathy or fibromyalgia is 60 mg daily. There's really no evidence that doses greater than 60 mg/day provide additional benefits.

DRUG INTERACTIONS: Duloxetine truly used in combination with a monoamine oxidase inhibitor (MAOI) for example phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), and selegiline (Eldepryl), or within 14 days of discontinuing the MAOI. At the very least Five days should be allowed after stopping duloxetine before you start an MAOI. Combinations of SNRIs and MAOIs could cause serious, sometimes fatal, reactions including quite high body's temperature, muscle rigidity, rapid fluctuations of pulse rate and hypertension, extreme agitation progressing to delirium, and coma. Similar reactions will occur if duloxetine is along with antipsychotics, tricyclic antidepressants and also other drugs which affect serotonin within the brain (by way of example, tryptophan, and sumatriptan (Imitrex).